Microsoft Word - CPS-6-JBC 2nd revised
نویسندگان
چکیده
Background: CPS-6 (EndoG) degrades chromosomal DNA during apoptosis. Results: Crystal structure of C. elegans CPS-6 was determined, and the DNA binding and cleavage mechanisms by CPS-6 were revealed. Conclusion: The DNase activity of CPS-6 is positively correlated with its pro-cell death activity. Significance: This study improves our general understanding of DNA hydrolysis by -metal finger nucleases and the process of apoptotic DNA fragmentation.
منابع مشابه
Microsoft Word - JBC manuscript 09-1-13
Background: The functional importance of C2 insert containing isoform of nonmuscle myosin II-C is not known.
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